Review on prenatal and pre-implantation genetic testing

A review published in Nature Reviews Genetics traces the history of prenatal and preimplantation genetic testing and its developments. It also provides an overview of progress in utilisation of genome-wide single-cell and cell-free foetal DNA. The review describes the key milestones from the period when the first prenatal genetic test was performed in 1966 and building of mouse models for pre-implantation genetic testing to the cutting edge technology that is available today. The article also describes the challenges associated with the technology, especially single-cell genome analysis as well as the helpfulness of these tests for identifying causes of developmental disorders.
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(source: Orphanews 20 Dec 2016)